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KMID : 0545120120220060832
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Journal of Microbiology and Biotechnology
2012 Volume.22 No. 6 p.832 ~ p.837
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Oxidative Potential of Some Endophytic Fungi Using 1-Indanone as a Substrate
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Taicia Pacheco Fill
Jose Vinicius da Silva
Kleber Thiago de Oliveira
Bianca Ferreira da Silva
Edson Rodrigues-Fo
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Abstract
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The oxidative potential of the fungus Penicillium brasilianum, a strain isolated as an endophyte from a Meliaceae plant (Melia azedarach), was investigated using 1-indanone as a substrate to track the production of monooxygenases. The fungus produced the dihydrocoumarin from 1-indanone with the classical Baeyer-Villiger reaction regiochemistry, and (-)-(R)-3-hydroxy-1-indanone with 78% ee. Minor compounds resulting from lipase and SAM activities were also detected. The biotransformation procedures were also applied to a collection of Penicillium and Aspergillus fungi obtained from M. azedarach and Murraya paniculata. The results showed that Baeyer-Villiger were mostly active in fungi isolated from M. azedarach. Almost all of the fungi tested produced 3-hydroxy-1-indanone..
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KEYWORD
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Biotransformation, BV oxidation, Endophytic, Penicillium, Aspergillus
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